Steerable laser probe

ABSTRACT

A steerable laser probe may include a handle, an actuation mechanism of the handle, an optic fiber, and a housing tube. The housing tube may include a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater than the first stiffness. The optic fiber may be disposed within the housing tube and within an inner bore of the handle. A portion of the optic fiber may be fixed to an inner portion of the housing tube.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. Provisional Application No.61/568,949, filed Dec. 9, 2011.

FIELD OF THE INVENTION

The present disclosure relates to a surgical instrument, and, moreparticularly, to a steerable laser probe.

BACKGROUND OF THE INVENTION

A wide variety of ophthalmic procedures require a laser energy source.For example, ophthalmic surgeons may use laser photocoagulation to treatproliferative retinopathy. Proliferative retinopathy is a conditioncharacterized by the development of abnormal blood vessels in the retinathat grow into the vitreous humor. Ophthalmic surgeons may treat thiscondition by energizing a laser to cauterize portions of the retina toprevent the abnormal blood vessels from growing and hemorrhaging.

In order to increase the chances of a successful laser photocoagulationprocedure, it is important that a surgeon is able aim the laser at aplurality of targets within the eye, e.g., by guiding or moving thelaser from a first target to a second target within the eye. It is alsoimportant that the surgeon is able to easily control a movement of thelaser. For example, the surgeon must be able to easily direct a laserbeam by steering the beam to a first position aimed at a first target,guide the laser beam from the first position to a second position aimedat a second target, and hold the laser beam in the second position.Accordingly, there is a need for a surgical laser probe that can beeasily guided to a plurality of targets within the eye.

BRIEF SUMMARY OF THE INVENTION

The present disclosure provides a steerable laser probe. In one or moreembodiments, a steerable laser probe may comprise a handle, an actuationmechanism of the handle, an optic fiber, and a housing tube.Illustratively, the housing tube may comprise a first housing tubeportion having a first stiffness and a second housing tube portionhaving a second stiffness. In one or more embodiments, the secondstiffness may be greater than the first stiffness. Illustratively, theoptic fiber may be disposed within the housing tube and within an innerbore of the handle. In one or more embodiments, a portion of the opticfiber may be fixed to an inner portion of the housing tube, e.g., by abiocompatible adhesive or any other suitable means.

Illustratively, an actuation of the actuation mechanism may beconfigured to gradually compress a first housing tube portion of thehousing tube. In one or more embodiments, a compression of the firsthousing tube portion may be configured to gradually curve the housingtube. Illustratively, a gradual curving of the housing tube may beconfigured to gradually curve the optic fiber.

In one or more embodiments, an actuation of the actuation mechanism maybe configured to gradually decompress a first housing tube portion ofthe housing tube. Illustratively, a decompression of the first housingtube portion may be configured to gradually straighten the housing tube.In one or more embodiments, a gradual straightening of the housing tubemay be configured to gradually straighten the optic fiber.

BRIEF DESCRIPTION OF THE DRAWINGS

The above and further advantages of the present invention may be betterunderstood by referring to the following description in conjunction withthe accompanying drawings in which like reference numerals indicateidentical or functionally similar elements:

FIGS. 1A and 1B are schematic diagrams illustrating an exploded view ofa handle assembly;

FIGS. 2A and 2B are schematic diagrams illustrating a handle;

FIGS. 3A, 3B, and 3C are schematic diagrams illustrating a housing tube;

FIG. 4 is a schematic diagram illustrating an exploded view of asteerable laser probe assembly;

FIGS. 5A, 5B, 5C, 5D, and 5E illustrate a gradual curving of an opticfiber;

FIGS. 6A, 6B, 6C, 6D, and 6E illustrate a gradual straightening of anoptic fiber;

FIGS. 7A and 7B are schematic diagrams illustrating an exploded view ofa handle assembly;

FIGS. 8A and 8B are schematic diagrams illustrating a handle;

FIGS. 9A and 9B are schematic diagrams illustrating an exploded view ofa handle assembly;

FIGS. 10A and 10B are schematic diagrams illustrating a handle;

FIGS. 11A, 11B, and 11C are schematic diagrams illustrating a housingtube;

FIG. 12 is a schematic diagram illustrating an exploded view of asteerable laser probe assembly;

FIGS. 13A, 13B, 13C, 13D, and 13E illustrate a gradual curving of anoptic fiber;

FIGS. 14A, 14B, 14C, 14D, and 14E illustrate a gradual straightening ofan optic fiber;

FIGS. 15A and 15B are schematic diagrams illustrating an exploded viewof a handle assembly;

FIGS. 16A and 16B are schematic diagrams illustrating a handle.

DETAILED DESCRIPTION OF AN ILLUSTRATIVE EMBODIMENT

FIGS. 1A and 1B are schematic diagrams illustrating an exploded view ofa handle assembly 100. FIG. 1A illustrates a side view of a handleassembly 100. In one or more embodiments, a handle assembly 100 maycomprise an outer cylinder 110 having an outer cylinder distal end 111and an outer cylinder proximal end 112, an actuation mechanism 120having an actuation mechanism distal end 121 and an actuation mechanismproximal end 122, and a handle base 140 having a handle base distal end141 and a handle base proximal end 142. Illustratively, actuationmechanism 120 may comprise an actuation control 130. In one or moreembodiments, actuation control 130 may comprise an actuation controldistal end 131 and an actuation control proximal end 132.Illustratively, handle base 140 may comprise an actuation channel 135having an actuation channel distal end 136 and an actuation channelproximal end 137. In one or more embodiments, handle base 140 maycomprise an outer cylinder interface 145. Illustratively, outer cylinderinterface 145 may be configured to interface with outer cylinder 110,e.g., outer cylinder interface 145 may be configured to interface withouter cylinder distal end 111. FIG. 1B illustrates a cross-sectionalview of a handle assembly 100. In one or more embodiments, a handleassembly 100 may comprise a fixation mechanism housing 150, an innerbore 160, an actuation mechanism guide 170, a handle base housing 171, ahousing tube housing 180, a housing tube guide 185, and a pressuremechanism housing 190. Illustratively, handle base housing 171 maycomprise a handle base interface 172. Outer cylinder 110, actuationmechanism 120, and handle base 140 may be manufactured from any suitablematerial, e.g., polymers, metals, metal alloys, etc., or from anycombination of suitable materials.

FIGS. 2A and 2B are schematic diagrams illustrating a handle 200. FIG.2A illustrates a side view of a handle 200. In one or more embodiments,handle 200 may comprise a handle distal end 201 and a handle proximalend 202. Illustratively, handle distal end 201 may comprise handle basedistal end 141. In one or more embodiments, handle proximal end 202 maycomprise outer cylinder proximal end 112. Illustratively, outer cylinderdistal end 111 may be disposed adjacent to outer cylinder interface 145.In one or more embodiments, actuation control 130 may be disposed withactuation channel 135.

FIG. 2B illustrates a cross-sectional view of a handle 200. In one ormore embodiments, a portion of handle base 140 may be disposed within aportion of outer cylinder 110. Illustratively, a portion of handle base140 may be disposed within handle base housing 171. In one or moreembodiments, a portion of handle base 140 may be disposed within handlebase housing 171 wherein handle base proximal end 142 may be disposedadjacent to handle base interface 172. Illustratively, actuationmechanism 120 may be disposed within actuation mechanism guide 170. Inone or more embodiments, actuation mechanism 120 may be configured toactuate within actuation mechanism guide 170. Illustratively, actuationcontrol 130 may be configured to control an actuation of actuationmechanism 120, e.g., within actuation mechanism guide 170.

In one or more embodiments, an actuation of actuation control 130 withinactuation channel 135 may be configured to actuate actuation mechanism120 within actuation mechanism guide 170. Illustratively, an actuationof actuation control distal end 131 towards actuation channel distal end136 may be configured to actuate actuation mechanism distal end 121towards handle distal end 201. In one or more embodiments, an actuationof actuation control proximal end 132 towards actuation channel proximalend 137 may be configured to actuate actuation mechanism proximal end122 towards handle proximal end 202. Illustratively, a pressuremechanism, e.g., a spring, may be disposed within pressure mechanismhousing 190. In one or more embodiments, a pressure mechanism may beconfigured to resist an actuation of actuation mechanism distal end 121towards handle distal end 201. Illustratively, a pressure mechanism maybe configured to facilitate an actuation of actuation mechanism proximalend 122 towards handle proximal end 202.

FIGS. 3A, 3B, and 3C are schematic diagrams illustrating a housing tube300. In one or more embodiments, housing tube 300 may comprise a housingtube distal end 301 and a housing tube proximal end 302. Housing tube300 may be manufactured from any suitable material, e.g., polymers,metals, metal alloys, etc., or from any combination of suitablematerials. FIG. 3A illustrates a housing tube 300 oriented to illustratea first housing tube portion 320. Illustratively, first housing tubeportion 320 may have a first stiffness. FIG. 3B illustrates a housingtube 300 oriented to illustrate a second housing tube portion 330.Illustratively, second housing tube portion 330 may have a secondstiffness. In one or more embodiments, the second stiffness may begreater than the first stiffness. Illustratively, first housing tubeportion 320 may comprise a first material having a first stiffness. Inone or more embodiments, second housing tube portion 330 may comprise asecond material having a second stiffness. Illustratively, the secondstiffness may be greater than the first stiffness.

In one or more embodiments, housing tube 300 may comprise a non-uniforminner diameter or a non-uniform outer diameter, e.g., to vary astiffness of one or more portions of housing tube 300. Illustratively, afirst housing tube portion 320 may comprise a first inner diameter ofhousing tube 300 and a second housing tube portion 330 may comprise asecond inner diameter of housing tube 300. In one or more embodiments,the first inner diameter of housing tube 300 may be larger than thesecond inner diameter of housing tube 300. Illustratively, a firsthousing tube portion 320 may comprise a first outer diameter of housingtube 300 and a second housing tube portion 330 may comprise a secondouter diameter of housing tube 300. In one or more embodiments, thefirst outer diameter of housing tube 300 may be smaller than the secondouter diameter of housing tube 300.

In one or more embodiments, first housing tube portion 320 may compriseone or more apertures configured to produce a first stiffness of firsthousing tube portion 320. Illustratively, second housing tube portion330 may comprise a solid portion of housing tube 300 having a secondstiffness. In one or more embodiments, the second stiffness may begreater than the first stiffness. Illustratively, first housing tubeportion 320 may comprise one or more apertures configured to produce afirst stiffness of first housing tube portion 320. In one or moreembodiments, second housing tube portion 330 may comprise one or moreapertures configured to produce a second stiffness of second housingtube portion 330. Illustratively, the second stiffness may be greaterthan the first stiffness.

In one or more embodiments, first housing tube portion 320 may comprisea plurality of slits configured to separate one or more solid portionsof housing tube 300. Illustratively, a plurality of slits may be cut,e.g., laser cut, into first housing tube portion 320. In one or moreembodiments, first housing tube portion 320 may comprise a plurality ofslits configured to minimize a force of friction between housing tube300 and a cannula, e.g., as housing tube 300 is inserted into thecannula or as housing tube 300 is extracted from the cannula. Forexample, each slit of the plurality of slits may comprise one or morearches configured to minimize a force of friction between housing tube300 and a cannula.

FIG. 3C illustrates an angled view of housing tube 300. Illustratively,an optic fiber 350 may be disposed within housing tube 300. In one ormore embodiments, optic fiber 350 may be disposed within housing tube300 wherein an optic fiber distal end 351 may be adjacent to housingtube distal end 301. Illustratively, optic fiber 350 may be disposedwithin housing tube 300 wherein a portion of optic fiber 350 may beadjacent to a portion of first housing tube portion 320. In one or moreembodiments, a portion of optic fiber 350 may be fixed to an innerportion of housing tube 300, e.g., by a biocompatible adhesive or anyother suitable means.

FIG. 4 is a schematic diagram illustrating an exploded view of asteerable laser probe assembly 400. In one or more embodiments, asteerable laser probe assembly 400 may comprise a handle assembly 100, ahousing tube 300 having a housing tube distal end 301 and a housing tubeproximal end 302, an optic fiber 350 having an optic fiber distal end351 and an optic fiber proximal end 352, a fixation mechanism 410, and alight source interface 420. Illustratively, light source interface 420may be configured to interface with optic fiber proximal end 352. In oneor more embodiments, light source interface 420 may comprise a standardlight source connecter, e.g., an SMA connector.

Illustratively, housing tube 300 may be disposed within housing tubehousing 180 and housing tube guide 185. In one or more embodiments,housing tube 300 may be fixed within housing tube housing 180, e.g.,housing tube proximal end 302 may be fixed within housing tube housing180. Illustratively, housing tube 300 may be fixed within housing tubehousing 180, e.g., by an adhesive or by any suitable fixation means. Inone or more embodiments, an actuation of actuation mechanism 120 may beconfigured to actuate housing tube 300. Illustratively, actuationcontrol 130 may be configured to control an actuation of housing tube300. In one or more embodiments, an actuation of actuation control 130within actuation channel 135 may be configured to actuate housing tube300 relative to handle base 140. Illustratively, an actuation ofactuation control distal end 131 towards actuation channel distal end136 may be configured to extend housing tube 300 relative to handleproximal end 202. In one or more embodiments, an actuation of actuationcontrol proximal end 132 towards actuation channel proximal end 137 maybe configured to retract housing tube 300 relative to handle proximalend 202.

Illustratively, optic fiber 350 may be disposed within inner bore 160,fixation mechanism housing 150, actuation mechanism guide 170, housingtube housing 180, housing tube guide 185, and housing tube 300. In oneor more embodiments, fixation mechanism 410 may be disposed withinfixation mechanism housing 150. Illustratively, fixation mechanism 410may be configured to fix optic fiber 350 in a position relative tohandle 200, e.g., at fixation mechanism housing 150. In one or moreembodiments, fixation mechanism 410 may comprise a set screw configuredto fix optic fiber 350 in a position relative to handle 200.Illustratively, optic fiber 350 may be fixed to fixation mechanism 410,e.g., by an adhesive or any suitable fixation means. For example,fixation mechanism 410 may be configured to fix optic fiber 350 in aposition relative to handle 200, e.g., by an interference fit configuredto fix optic fiber 350 in a position relative to handle 200 withoutdamaging optic fiber 350. In one or more embodiments, a portion of opticfiber 350 may be fixed to an inner portion of housing tube 300, e.g., byan adhesive or any suitable fixation means. Illustratively, optic fiber350 may be fixed in a position relative to handle 200, e.g., by fixationmechanism 410, and optic fiber 350 may also be fixed to an inner portionof housing tube 300, e.g., a first housing tube portion 320.

In one or more embodiments, an actuation of actuation mechanism 120 maybe configured to actuate housing tube 300 relative to optic fiber 350.Illustratively, actuation control 130 may be configured to control anactuation of actuation mechanism 120 and housing tube 300. In one ormore embodiments, an actuation of actuation control distal end 131towards actuation channel distal end 136 may be configured to actuateactuation mechanism distal end 121 towards handle distal end 201.Illustratively, an actuation of actuation mechanism distal end 121towards handle distal end 201 may be configured to extend housing tube300 relative to optic fiber 350 and handle proximal end 202. In one ormore embodiments, an actuation of actuation control proximal end 132towards actuation channel proximal end 137 may be configured to actuateactuation mechanism proximal end 122 towards handle proximal end 202.Illustratively, an actuation of actuation mechanism proximal end 122towards handle proximal end 202 may be configured to retract housingtube 300 relative to optic fiber 350 and handle proximal end 202.

In one or more embodiments, optic fiber 350 may be configured to resistan extension of housing tube 300 relative to handle proximal end 202.Illustratively, optic fiber 350 may be fixed in a position relative tohandle 200, e.g., by fixation mechanism 410, and a portion of opticfiber 350 may be fixed to an inner portion of housing tube 300, e.g., afirst housing tube portion 320. In one or more embodiments, as housingtube 300 is extended relative to handle proximal end 202, e.g., due toan actuation of actuation mechanism distal end 121 towards handle distalend 201, optic fiber 350 may be configured to resist the extension ofhousing tube 300 relative to handle proximal end 202. Illustratively, ashousing tube 300 is gradually extended relative to handle proximal end202, optic fiber 350 may be configured to gradually compress a portionof housing tube 300, e.g., a first housing tube portion 320, causinghousing tube 300 to gradually curve. In one or more embodiments, agradual curving of housing tube 300 may be configured to gradually curveoptic fiber 350.

Illustratively, a retraction of housing tube 300 relative to handleproximal end 202, e.g., due to an actuation of actuation mechanismproximal end 122 towards handle proximal end 202, may be configured toreduce a compressive force applied, e.g., by optic fiber 350, to aportion of housing tube 300. In one or more embodiments, a gradualrefraction of housing tube 300 relative to handle proximal end 202 maybe configured to gradually decompress a portion of housing tube 300,e.g., a first housing tube portion 320, causing housing tube 300 togradually straighten. Illustratively, a gradual straightening of housingtube 300 may be configured to gradually straighten optic fiber 350.

In one or more embodiments, an extension of actuation control 130relative to handle proximal end 202 may comprise an actuation ofactuation control distal end 131 towards actuation channel distal end136. Illustratively, actuation control 130 may be fully extendedrelative to handle proximal end 202, e.g., when actuation control distalend 131 is adjacent to actuation channel distal end 136. In one or moreembodiments, an extension of actuation mechanism 120 relative to handleproximal end 202 may comprise an actuation of actuation mechanism distalend 121 towards handle distal end 201. Illustratively, an extension ofactuation control 130 relative to handle proximal end 202 may beconfigured to cause an extension of actuation mechanism 120 relative tohandle proximal end 202. In one or more embodiments, an extension ofactuation mechanism 120 relative to handle proximal end 202 may beconfigured to extend housing tube 300 relative to handle proximal end202 and optic fiber 350. Illustratively, an extension of housing tube300 relative to optic fiber 350 may be configured to curve housing tube300. In one or more embodiments, a curving of housing tube 300 may beconfigured to curve optic fiber 350.

In one or more embodiments, a retraction of actuation control 130relative to handle proximal end 202 may comprise an actuation ofactuation control proximal end 132 towards actuation channel proximalend 137. Illustratively, actuation control 130 may be fully retractedrelative to handle proximal end 202, e.g., when actuation controlproximal end 132 is adjacent to actuation channel proximal end 137. Inone or more embodiments, a retraction of actuation mechanism 120relative to handle proximal end 202 may comprise an actuation ofactuation mechanism proximal end 122 towards handle proximal end 202.Illustratively, a retraction of actuation control 130 relative to handleproximal end 202 may be configured to cause a refraction of actuationmechanism 120 relative to handle proximal end 202. In one or moreembodiments, a refraction of actuation mechanism 120 relative to handleproximal end 202 may be configured to retract housing tube 300 relativeto handle proximal end 202 and optic fiber 350. Illustratively, aretraction of housing tube 300 relative to optic fiber 350 may beconfigured to straighten housing tube 300. In one or more embodiments, astraightening of housing tube 300 may be configured to straighten opticfiber 350.

FIGS. 5A, 5B, 5C, 5D, and 5E illustrate a gradual curving of an opticfiber 350. FIG. 5A illustrates a straight optic fiber 500. In one ormore embodiments, optic fiber 350 may comprise a straight optic fiber500, e.g., when actuation control 130 is fully retracted relative tohandle proximal end 202. Illustratively, optic fiber 350 may comprise astraight optic fiber 500, e.g., when first housing tube portion 320 isfully decompressed. In one or more embodiments, a line tangent to opticfiber distal end 351 may be parallel to a line tangent to housing tubeproximal end 302, e.g., when optic fiber 350 comprises a straight opticfiber 500.

FIG. 5B illustrates an optic fiber in a first curved position 510.Illustratively, an extension of actuation control 130 relative to handleproximal end 202 may be configured to extend housing tube 300 relativeto optic fiber 350. In one or more embodiments, an extension of housingtube 300 relative to optic fiber 350 may be configured to cause opticfiber 350 to compress a portion of housing tube 300 causing housing tube300 to gradually curve. Illustratively, a gradual curving of housingtube 300 may be configured to gradually curve optic fiber 350. In one ormore embodiments, an extension of actuation control 130 relative tohandle proximal end 202 may be configured to gradually curve optic fiber350 from a straight optic fiber 500 to an optic fiber in a first curvedposition 510. Illustratively, an extension of actuation mechanism 120relative to handle proximal end 202 may be configured to extend housingtube 300 relative to optic fiber 350. In one or more embodiments, anextension of housing tube 300 relative to optic fiber 350 may beconfigured to gradually curve optic fiber 350 from a straight opticfiber 500 to an optic fiber in a first curved position 510.Illustratively, a line tangent to optic fiber distal end 351 mayintersect a line tangent to housing tube proximal end 302 at a firstangle, e.g., when optic fiber 350 comprises an optic fiber in a firstcurved position 510. In one or more embodiments, the first angle maycomprise any angle greater than zero degrees. For example, the firstangle may comprise a 45 degree angle.

FIG. 5C illustrates an optic fiber in a second curved position 520.Illustratively, an extension of actuation control 130 relative to handleproximal end 202 may be configured to extend housing tube 300 relativeto optic fiber 350. In one or more embodiments, an extension of housingtube 300 relative to optic fiber 350 may be configured to cause opticfiber 350 to compress a portion of housing tube 300 causing housing tube300 to gradually curve. Illustratively, a gradual curving of housingtube 300 may be configured to gradually curve optic fiber 350. In one ormore embodiments, an extension of actuation control 130 relative tohandle proximal end 202 may be configured to gradually curve optic fiber350 from an optic fiber in a first curved position 510 to an optic fiberin a second curved position 520. Illustratively, an extension ofactuation mechanism 120 relative to handle proximal end 202 may beconfigured to extend housing tube 300 relative to optic fiber 350. Inone or more embodiments, an extension of housing tube 300 relative tooptic fiber 350 may be configured to gradually curve optic fiber 350from an optic fiber in a first curved position 510 to an optic fiber ina second curved position 520. Illustratively, a line tangent to opticfiber distal end 351 may intersect a line tangent to housing tubeproximal end 302 at a second angle, e.g., when optic fiber 350 comprisesan optic fiber in a second curved position 520. In one or moreembodiments, the second angle may comprise any angle greater than thefirst angle. For example, the second angle may comprise a 90 degreeangle.

FIG. 5D illustrates an optic fiber in a third curved position 530.Illustratively, an extension of actuation control 130 relative to handleproximal end 202 may be configured to extend housing tube 300 relativeto optic fiber 350. In one or more embodiments, an extension of housingtube 300 relative to optic fiber 350 may be configured to cause opticfiber 350 to compress a portion of housing tube 300 causing housing tube300 to gradually curve. Illustratively, a gradual curving of housingtube 300 may be configured to gradually curve optic fiber 350. In one ormore embodiments, an extension of actuation control 130 relative tohandle proximal end 202 may be configured to gradually curve optic fiber350 from an optic fiber in a second curved position 520 to an opticfiber in a third curved position 530. Illustratively, an extension ofactuation mechanism 120 relative to handle proximal end 202 may beconfigured to extend housing tube 300 relative to optic fiber 350. Inone or more embodiments, an extension of housing tube 300 relative tooptic fiber 350 may be configured to gradually curve optic fiber 350from an optic fiber in a second curved position 520 to an optic fiber ina third curved position 530. Illustratively, a line tangent to opticfiber distal end 351 may intersect a line tangent to housing tubeproximal end 302 at a second angle, e.g., when optic fiber 350 comprisesan optic fiber in a third curved position 530. In one or moreembodiments, the third angle may comprise any angle greater than thesecond angle. For example, the third angle may comprise a 135 degreeangle.

FIG. 5E illustrates an optic fiber in a fourth curved position 540.Illustratively, an extension of actuation control 130 relative to handleproximal end 202 may be configured to extend housing tube 300 relativeto optic fiber 350. In one or more embodiments, an extension of housingtube 300 relative to optic fiber 350 may be configured to cause opticfiber 350 to compress a portion of housing tube 300 causing housing tube300 to gradually curve. Illustratively, a gradual curving of housingtube 300 may be configured to gradually curve optic fiber 350. In one ormore embodiments, an extension of actuation control 130 relative tohandle proximal end 202 may be configured to gradually curve optic fiber350 from an optic fiber in a third curved position 530 to an optic fiberin a fourth curved position 540. Illustratively, an extension ofactuation mechanism 120 relative to handle proximal end 202 may beconfigured to extend housing tube 300 relative to optic fiber 350. Inone or more embodiments, an extension of housing tube 300 relative tooptic fiber 350 may be configured to gradually curve optic fiber 350from an optic fiber in a third curved position 530 to an optic fiber ina fourth curved position 540. For example, a line tangent to optic fiberdistal end 351 may be parallel to a line tangent to housing tubeproximal end 302, e.g., when optic fiber 350 comprises an optic fiber ina fourth curved position 540.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a stiffness of first housing tube portion320 or a stiffness of second housing tube portion 330 may be adjusted tovary an amount of actuation of actuation mechanism 120 configured tocurve housing tube 300 to a particular curved position. Illustratively,a material comprising first housing tube portion 320 or a materialcomprising second housing tube portion 330 may be adjusted to vary anamount of actuation of actuation mechanism 120 configured to curvehousing tube 300 to a particular curved position. In one or moreembodiments, an inner diameter of first housing tube portion 320 or aninner diameter of second housing tube portion 330 may be adjusted tovary an amount of actuation structure 120 configured to curve housingtube 300 to a particular curved position. Illustratively, an outerdiameter of first housing tube portion 320 or an outer diameter ofsecond housing tube portion 330 may be adjusted to vary an amount ofactuation structure 120 configured to curve housing tube 300 to aparticular curved position.

In one or more embodiments, a number of apertures in housing tube 300may be adjusted to vary an amount of actuation of actuation mechanism120 configured to curve housing tube 300 to a particular curvedposition. Illustratively, a location of one or more apertures in housingtube 300 may be adjusted to vary an amount of actuation of actuationmechanism 120 configured to curve housing tube 300 to a particularcurved position. In one or more embodiments, a geometry of one or moreapertures in housing tube 300 may be adjusted to vary an amount ofactuation of actuation mechanism 120 configured to curve housing tube300 to a particular curved position. Illustratively, a geometry of oneor more apertures in housing tube 300 may be uniform, e.g., eachaperture of the one or more apertures may have a same geometry. In oneor more embodiments, a geometry of one or more apertures in housing tube300 may be non-uniform, e.g., a first aperture in housing tube 300 mayhave a first geometry and a second aperture in housing tube 300 may havea second geometry.

Illustratively, a geometry or shape of actuation mechanism 120 may beadjusted to vary an amount actuation of actuation mechanism 120configured to curve housing tube 300 to a particular curved position. Inone or more embodiments, one or more locations within housing tube 300wherein optic fiber 350 may be fixed to an inner portion of housing tube300 may be adjusted to vary an amount of actuation of actuationmechanism 120 configured to curve housing tube 300 to a particularcurved position. Illustratively, at least a portion of optic fiber 350may be enclosed in an optic fiber sleeve configured to, e.g., protectoptic fiber 350, vary a stiffness of optic fiber 350, vary an opticalproperty of optic fiber 350, etc. For example, a portion of optic fiber350 that may be fixed to fixam tion mechanism 410, e.g., at fixationmechanism housing 150, may be enclosed in an optic fiber sleeveconfigured to, e.g., protect optic fiber 350, facilitate a fixation,etc. In one or more embodiments, a portion of optic fiber 350 that maybe fixed to an inner portion of housing tube 300 may be enclosed in anoptic fiber sleeve configured to, e.g., protect optic fiber 350,facilitate a fixation, etc. Illustratively, a portion of housing tube300 may comprise an access window, e.g., configured to allow access toan inner portion of housing tube 300. In one or more embodiments, aportion of housing tube 300 may comprise an access window, e.g.,configured to allow access to a portion of optic fiber 350.

Illustratively, a stiffness of first housing tube portion 320 or astiffness of second housing tube portion 330 may be adjusted to vary abend radius of housing tube 300. In one or more embodiments, a stiffnessof first housing tube portion 320 or a stiffness of second housing tubeportion 330 may be adjusted to vary a radius of curvature of housingtube 300, e.g., when housing tube 300 is in a particular curvedposition. Illustratively, a number of apertures in housing tube 300 maybe adjusted to vary a bend radius of housing tube 300. In one or moreembodiments, a number of apertures in housing tube 300 may be adjustedto vary a radius of curvature of housing tube 300, e.g., when housingtube 300 is in a particular curved position. Illustratively, a locationor a geometry of one or more apertures in housing tube 300 may beadjusted to vary a bend radius of housing tube 300. In one or moreembodiments, a location or a geometry of one or more apertures inhousing tube 300 may be adjusted to vary a radius of curvature ofhousing tube 300, e.g., when housing tube 300 is in a particular curvedposition.

FIGS. 6A, 6B, 6C, 6D, and 6E illustrate a gradual straightening of anoptic fiber 350. FIG. 6A illustrates a fully curved optic fiber 600. Inone or more embodiments, optic fiber 350 may comprise a fully curvedoptic fiber 600, e.g., when actuation control 130 is fully extendedrelative to handle proximal end 202. Illustratively, optic fiber 350 maycomprise a fully curved optic fiber 600, e.g., when first housing tubeportion 320 is fully compressed. In one or more embodiments, a linetangent to optic fiber distal end 351 may be parallel to a line tangentto housing tube proximal end 302, e.g., when optic fiber 350 comprises astraight optic fiber 600.

FIG. 6B illustrates an optic fiber in a first partially straightenedposition 610. Illustratively, a retraction of actuation control 130relative to handle proximal end 202 may be configured to retract housingtube 300 relative to optic fiber 350. In one or more embodiments, aretraction of housing tube 300 relative to optic fiber 350 may beconfigured to cause optic fiber 350 to decompress a portion of housingtube 300, e.g., a first housing tube portion 320, causing housing tube300 to gradually straighten. Illustratively, a gradual straightening ofhousing tube 300 may be configured to gradually straighten optic fiber350. In one or more embodiments, a retraction of actuation control 130relative to handle proximal end 202 may be configured to graduallystraighten optic fiber 350 from a fully curved optic fiber 600 to anoptic fiber in a first partially straightened position 610.Illustratively, a refraction of actuation mechanism 120 relative tohandle proximal end 202 may be configured to retract housing tube 300relative to optic fiber 350. In one or more embodiments, a retraction ofhousing tube 300 relative to optic fiber 350 may be configured togradually straighten optic fiber 350 from a fully curved optic fiber 600to an optic fiber in a first partially straightened position 610.Illustratively, a line tangent to optic fiber distal end 351 mayintersect a line tangent to housing tube proximal end 302 at a firstpartially straightened angle, e.g., when optic fiber 350 comprises anoptic fiber in a first partially straightened position 610.Illustratively, the first partially straightened angle may comprise anyangle less than 180 degrees. For example, the first partiallystraightened angle may comprise a 135 degree angle.

FIG. 6C illustrates an optic fiber in a second partially straightenedposition 620. Illustratively, a retraction of actuation control 130relative to handle proximal end 202 may be configured to retract housingtube 300 relative to optic fiber 350. In one or more embodiments, aretraction of housing tube 300 relative to optic fiber 350 may beconfigured to cause optic fiber 350 to decompress a portion of housingtube 300, e.g., a first housing tube portion 320, causing housing tube300 to gradually straighten. Illustratively, a gradual straightening ofhousing tube 300 may be configured to gradually straighten optic fiber350. In one or more embodiments, a retraction of actuation control 130relative to handle proximal end 202 may be configured to graduallystraighten optic fiber 350 from an optic fiber in a first partiallystraightened position 610 to an optic fiber in a second partiallystraightened position 620. Illustratively, a retraction of actuationmechanism 120 relative to handle proximal end 202 may be configured toretract housing tube 300 relative to optic fiber 350. In one or moreembodiments, a refraction of housing tube 300 relative to optic fiber350 may be configured to gradually straighten optic fiber 350 from anoptic fiber in a first partially straightened position 610 to an opticfiber in a second partially straightened position 620. Illustratively, aline tangent to optic fiber distal end 351 may intersect a line tangentto housing tube proximal end 302 at a second partially straightenedangle, e.g., when optic fiber 350 comprises an optic fiber in a secondpartially straightened position 620. Illustratively, the secondpartially straightened angle may comprise any angle less than the firstpartially straightened angle. For example, the second partiallystraightened angle may comprise a 90 degree angle.

FIG. 6D illustrates an optic fiber in a third partially straightenedposition 630. Illustratively, a retraction of actuation control 130relative to handle proximal end 202 may be configured to retract housingtube 300 relative to optic fiber 350. In one or more embodiments, aretraction of housing tube 300 relative to optic fiber 350 may beconfigured to cause optic fiber 350 to decompress a portion of housingtube 300, e.g., a first housing tube portion 320, causing housing tube300 to gradually straighten. Illustratively, a gradual straightening ofhousing tube 300 may be configured to gradually straighten optic fiber350. In one or more embodiments, a retraction of actuation control 130relative to handle proximal end 202 may be configured to graduallystraighten optic fiber 350 from an optic fiber in a second partiallystraightened position 620 to an optic fiber in a third partiallystraightened position 630. Illustratively, a retraction of actuationmechanism 120 relative to handle proximal end 202 may be configured toretract housing tube 300 relative to optic fiber 350. In one or moreembodiments, a refraction of housing tube 300 relative to optic fiber350 may be configured to gradually straighten optic fiber 350 from anoptic fiber in a second partially straightened position 620 to an opticfiber in a third partially straightened position 630. Illustratively, aline tangent to optic fiber distal end 351 may intersect a line tangentto housing tube proximal end 302 at a third partially straightenedangle, e.g., when optic fiber 350 comprises an optic fiber in a thirdpartially straightened position 630. Illustratively, the third partiallystraightened angle may comprise any angle less than the second partiallystraightened angle. For example, the third partially straightened anglemay comprise a 45 degree angle.

FIG. 6E illustrates an optic fiber in a fully straightened position 640.Illustratively, a retraction of actuation control 130 relative to handleproximal end 202 may be configured to retract housing tube 300 relativeto optic fiber 350. In one or more embodiments, a refraction of housingtube 300 relative to optic fiber 350 may be configured to cause opticfiber 350 to decompress a portion of housing tube 300, e.g., a firsthousing tube portion 320, causing housing tube 300 to graduallystraighten. Illustratively, a gradual straightening of housing tube 300may be configured to gradually straighten optic fiber 350. In one ormore embodiments, a retraction of actuation control 130 relative tohandle proximal end 202 may be configured to gradually straighten opticfiber 350 from an optic fiber in a third partially straightened position630 to an optic fiber in a fully straightened position 640.Illustratively, a retraction of actuation mechanism 120 relative tohandle proximal end 202 may be configured to retract housing tube 300relative to optic fiber 350. In one or more embodiments, a retraction ofhousing tube 300 relative to optic fiber 350 may be configured togradually straighten optic fiber 350 from an optic fiber in a thirdpartially straightened position 630 to an optic fiber in a fullystraightened position 640. Illustratively, a line tangent to optic fiberdistal end 351 may be parallel to a line tangent to housing tubeproximal end 302, e.g., when optic fiber 350 comprises an optic fiber ina fully straightened position 640.

Illustratively, a surgeon may aim optic fiber distal end 351 at any of aplurality of targets within an eye, e.g., to perform a photocoagulationprocedure. In one or more embodiments, a surgeon may aim optic fiberdistal end 351 at any target within a particular transverse plane of theinner eye by, e.g., rotating handle 200 to orient housing tube 300 in anorientation configured to cause a curvature of housing tube 300 withinthe particular transverse plane of the inner eye and varying an amountof actuation of actuation mechanism 120. Illustratively, a surgeon mayaim optic fiber distal end 351 at any target within a particularsagittal plane of the inner eye by, e.g., rotating handle 200 to orienthousing tube 300 in an orientation configured to cause a curvature ofhousing tube 300 within the particular sagittal plane of the inner eyeand varying an amount of actuation of actuation mechanism 120. In one ormore embodiments, a surgeon may aim optic fiber distal end 351 at anytarget within a particular frontal plane of the inner eye by, e.g.,varying an amount of actuation of actuation mechanism 120 to orient aline tangent to optic fiber distal end 351 wherein the line tangent tooptic fiber distal end 351 is within the particular frontal plane of theinner eye and rotating handle 200. Illustratively, a surgeon may aimoptic fiber distal end 351 at any target located outside of theparticular transverse plane, the particular sagittal plane, and theparticular frontal plane of the inner eye, e.g., by varying a rotationalorientation of handle 200 and varying an amount of actuation ofactuation mechanism 120. In one or more embodiments, a surgeon may aimoptic fiber distal end 351 at any target of a plurality of targetswithin an eye, e.g., without increasing a length of a portion of asteerable laser probe within the eye. Illustratively, a surgeon may aimoptic fiber distal end 351 at any target of a plurality of targetswithin an eye, e.g., without decreasing a length of a portion of asteerable laser probe within the eye.

FIGS. 7A and 7B are schematic diagrams illustrating an exploded view ofa handle assembly 700. FIG. 7A illustrates a side view of a handleassembly 700. In one or more embodiments, a handle assembly 700 maycomprise an outer cylinder 110, an actuation mechanism 120, and a handlebase 140. Illustratively, actuation mechanism 120 may comprise anactuation control 130. In one or more embodiments, handle base 140 maycomprise an actuation channel 135. Illustratively, actuation mechanism120 may comprise an actuation chamber 710. FIG. 7B illustrates across-sectional top view of a handle assembly 700. In one or moreembodiments, handle base 140 may comprise one or more static chambers720.

FIGS. 8A and 8B are schematic diagrams illustrating a handle 800. FIG.8A illustrates a transparent top view of handle 800. In one or moreembodiments, actuation control 130 may be disposed within actuationchannel 135. FIG. 8B illustrates a transparent side view of handle 800.Illustratively, an actuation chamber 710 may be configured to align withone or more static chambers 720. In one or more embodiments, one or morestatic chambers 720 may be configured to temporarily fix actuationcontrol 130 in a position within actuation channel 135. For example, afirst static chamber 720 may be configured to temporarily fix actuationcontrol 130 in a first position within actuation channel 135, a secondstatic chamber 720 may be configured to temporarily fix actuationcontrol 130 in a second position within actuation channel 135, a thirdstatic chamber 720 may be configured to temporarily fix actuationcontrol 130 in a third position within actuation channel 135, a forthstatic chamber 720 may be configured to temporarily fix actuationcontrol 130 in a forth position within actuation channel 135, etc.

Illustratively, a static chamber 720 may be configured to interface withactuation chamber 710, e.g., to temporarily fix actuation control 130 ina position within actuation channel 135. In one or more embodiments, aninterface between a static chamber 720 and actuation chamber 710 may beconfigured to align a static chamber 720 and actuation chamber 710wherein a fixation pin may be temporarily disposed within a staticchamber 720 and within actuation chamber 710. Illustratively, a fixationpin may be temporarily disposed within a static chamber 720 and withinactuation chamber 710, e.g., by pushing the fixation pin into a staticchamber 720 and into actuation chamber 710. In one or more embodiments,actuation control 130 may be temporarily fixed in a position withinactuation channel 135, e.g., when a fixation pin is disposed within astatic chamber 720 and within actuation chamber 710. Illustratively,removing a fixation pin from actuation chamber 710 may be configured toallow actuation control 130 actuate within actuation channel 135. In oneor more embodiments, a fixation pin may be removed from actuationchamber 710, e.g., by pulling the fixation pin out of actuation chamber710.

Illustratively, one or more static chambers 720 may be configured tohouse one or more magnets. In one or more embodiments, actuation chamber710 may be configured to house one or more magnets. Illustratively, oneor more magnets may be configured to temporarily fix actuation control130 in a position within actuation channel 135. In one or moreembodiments, one or more magnets may be disposed within a static chamber720 wherein one or more magnetic poles of the one or more magnets may beoriented to cause an attractive force between one or more magnets andactuation control 130, e.g., when actuation chamber 710 is adjacent to astatic chamber 720. Illustratively, one or more magnets may be disposedwithin actuation chamber 710 wherein one or more magnetic poles of theone or more magnets may be oriented to cause an attractive force betweenone or more magnets and a static chamber 720, e.g., when actuationchamber 710 is adjacent to a static chamber 720. In one or moreembodiments, one or more magnets may be configured to cause one or moreattractive forces configured to temporarily fix actuation control 130 ina position within actuation channel 135. For example, an attractiveforce configured to temporarily fix actuation control 130 in a positionwithin actuation channel 135 may have a magnitude in the range of 1 to50 N. However, an attractive force configured to temporarily fixactuation control 130 in a position within actuation channel 135 mayhave a magnitude less than 1 N or a magnitude greater than 50 N.Illustratively, an application of a force, e.g., a force having amagnitude greater than a magnitude of an attractive force, to actuationcontrol 130 may be configured to actuate actuation control 130 withinactuation channel 135.

In one or more embodiments, temporarily fixing actuation control 130 ina position within actuation channel 135 may be configured to temporarilyfix housing tube 300 in a particular curved position. Illustratively,temporarily fixing housing tube 300 in a particular curved position maybe configured to temporarily fix optic fiber 350 in a particular curvedposition. In one or more embodiments, a first static chamber 720 may beconfigured to temporarily fix housing tube 300 in a particular curvedposition wherein optic fiber 350 may comprise an optic fiber in a firstcurved position 510, a second static chamber 720 may be configured totemporarily fix housing tube 300 in a particular curved position whereinoptic fiber 350 may comprise an optic fiber in a second curved position520, a third static chamber 720 may be configured to temporarily fixhousing tube 300 in a particular curved position wherein optic fiber 350may comprise an optic fiber in a third curved position 530, a fourthstatic chamber 720 may be configured to temporarily fix housing tube 300in a particular curved position wherein optic fiber 350 may comprise anoptic fiber in a fourth curved position 540, etc.

FIGS. 9A and 9B are schematic diagrams illustrating an exploded view ofa handle assembly 900. FIG. 9A illustrates a side view of a handleassembly 900. In one or more embodiments, a handle assembly 900 maycomprise an outer cylinder 910 having an outer cylinder distal end 911and an outer cylinder proximal end 912, an actuation mechanism 920having an actuation mechanism distal end 921 and an actuation mechanismproximal end 922, and a handle base 940 having a handle base distal end941 and a handle base proximal end 942. Illustratively, actuationmechanism 920 may comprise an actuation control 930. In one or moreembodiments, actuation control 930 may comprise an actuation controldistal end 931 and an actuation control proximal end 932.Illustratively, handle base 940 may comprise an actuation channel 935having an actuation channel distal end 936 and an actuation channelproximal end 937. In one or more embodiments, handle base 940 maycomprise an outer cylinder interface 945. Illustratively, outer cylinderinterface 945 may be configured to interface with outer cylinder 910,e.g., outer cylinder interface 945 may be configured to interface withouter cylinder distal end 911. FIG. 9B illustrates a cross-sectionalview of a handle assembly 900. In one or more embodiments, a handleassembly 900 may comprise a fixation mechanism housing 950, an innerbore 960, an actuation mechanism guide 970, a handle base housing 971, ahousing tube housing 980, a housing tube guide 985, and a pressuremechanism housing 990. Illustratively, handle base housing 971 maycomprise a handle base interface 972. Outer cylinder 910, actuationmechanism 920, and handle base 940 may be manufactured from any suitablematerial, e.g., polymers, metals, metal alloys, etc., or from anycombination of suitable materials.

FIGS. 10A and 10B are schematic diagrams illustrating a handle 1000.FIG. 10A illustrates a side view of a handle 1000. In one or moreembodiments, handle 1000 may comprise a handle distal end 1001 and ahandle proximal end 1002. Illustratively, handle distal end 1001 maycomprise handle base distal end 941. In one or more embodiments, handleproximal end 1002 may comprise outer cylinder proximal end 912.Illustratively, outer cylinder distal end 911 may be disposed adjacentto outer cylinder interface 945. In one or more embodiments, actuationcontrol 930 may be disposed with actuation channel 935.

FIG. 10B illustrates a cross-sectional view of a handle 1000. In one ormore embodiments, a portion of handle base 940 may be disposed within aportion of outer cylinder 910. Illustratively, a portion of handle base940 may be disposed within handle base housing 971. In one or moreembodiments, a portion of handle base 940 may be disposed within handlebase housing 971 wherein handle base proximal end 942 may be disposedadjacent to handle base interface 972. Illustratively, actuationmechanism 920 may be disposed within actuation mechanism guide 970. Inone or more embodiments, actuation mechanism 920 may be configured toactuate within actuation mechanism guide 970. Illustratively, actuationcontrol 930 may be configured to control an actuation of actuationmechanism 920, e.g., within actuation mechanism guide 970.

In one or more embodiments, an actuation of actuation control 930 withinactuation channel 935 may be configured to actuate actuation mechanism920 within actuation mechanism guide 970. Illustratively, an actuationof actuation control distal end 931 towards actuation channel distal end936 may be configured to actuate actuation mechanism distal end 921towards handle distal end 1001. In one or more embodiments, an actuationof actuation control proximal end 932 towards actuation channel proximalend 937 may be configured to actuate actuation mechanism proximal end922 towards handle proximal end 1002. Illustratively, a pressuremechanism, e.g., a spring, may be disposed within pressure mechanismhousing 990. In one or more embodiments, a pressure mechanism may beconfigured to resist an actuation of actuation mechanism distal end 921towards handle distal end 1001. Illustratively, a pressure mechanism maybe configured to facilitate an actuation of actuation mechanism proximalend 922 towards handle proximal end 1002.

FIGS. 11A, 11B, and 11C are schematic diagrams illustrating a housingtube 1100. In one or more embodiments, housing tube 1100 may comprise ahousing tube distal end 1101 and a housing tube proximal end 1102.Housing tube 1100 may be manufactured from any suitable material, e.g.,polymers, metals, metal alloys, etc., or from any combination ofsuitable materials. FIG. 11A illustrates a housing tube 1100 oriented toillustrate a first housing tube portion 1120. Illustratively, firsthousing tube portion 1120 may have a first stiffness. FIG. 11Billustrates a housing tube 1100 oriented to illustrate a second housingtube portion 1130. Illustratively, second housing tube portion 1130 mayhave a second stiffness. In one or more embodiments, the secondstiffness may be greater than the first stiffness. Illustratively, firsthousing tube portion 1120 may comprise a first material having a firststiffness. In one or more embodiments, second housing tube portion 1130may comprise a second material having a second stiffness.Illustratively, the second stiffness may be greater than the firststiffness.

In one or more embodiments, housing tube 1100 may comprise a non-uniforminner diameter or a non-uniform outer diameter, e.g., to vary astiffness of one or more portions of housing tube 1100. Illustratively,a first housing tube portion 1120 may comprise a first inner diameter ofhousing tube 1100 and a second housing tube portion 1130 may comprise asecond inner diameter of housing tube 1100. In one or more embodiments,the first inner diameter of housing tube 1100 may be larger than thesecond inner diameter of housing tube 1100. Illustratively, a firsthousing tube portion 1120 may comprise a first outer diameter of housingtube 1100 and a second housing tube portion 1130 may comprise a secondouter diameter of housing tube 1100. In one or more embodiments, thefirst outer diameter of housing tube 1100 may be smaller than the secondouter diameter of housing tube 1100.

In one or more embodiments, first housing tube portion 1120 may compriseone or more apertures configured to produce a first stiffness of firsthousing tube portion 1120. Illustratively, second housing tube portion1130 may comprise a solid portion of housing tube 1100 having a secondstiffness. In one or more embodiments, the second stiffness may begreater than the first stiffness. Illustratively, first housing tubeportion 1120 may comprise one or more apertures configured to produce afirst stiffness of first housing tube portion 1120. In one or moreembodiments, second housing tube portion 1130 may comprise one or moreapertures configured to produce a second stiffness of second housingtube portion 1130. Illustratively, the second stiffness may be greaterthan the first stiffness.

In one or more embodiments, first housing tube portion 1120 may comprisea plurality of slits configured to separate one or more solid portionsof housing tube 1100. Illustratively, a plurality of slits may be cut,e.g., laser cut, into first housing tube portion 1120. In one or moreembodiments, first housing tube portion 1120 may comprise a plurality ofslits configured to minimize a force of friction between housing tube1100 and a cannula, e.g., as housing tube 1100 is inserted into thecannula or as housing tube 1100 is extracted from the cannula. Forexample, each slit of the plurality of slits may comprise one or morearches configured to minimize a force of friction between housing tube1100 and a cannula.

FIG. 11C illustrates an angled view of housing tube 1100.Illustratively, an optic fiber 1150 may be disposed within housing tube1100. In one or more embodiments, optic fiber 1150 may be disposedwithin housing tube 1100 wherein an optic fiber distal end 1151 isadjacent to housing tube distal end 1101. Illustratively, optic fiber1150 may be disposed within housing tube 1100 wherein a portion of opticfiber 1150 may be adjacent to a portion of first housing tube portion1120. In one or more embodiments, a portion of optic fiber 1150 may befixed to an inner portion of housing tube 1100, e.g., by a biocompatibleadhesive or any other suitable means.

Illustratively, a wire 1140 may be disposed within housing tube 1100. Inone or more embodiments, wire 1140 may be disposed within housing tube1100 wherein a wire distal end 1141 may be adjacent to housing tubedistal end 1101. Illustratively, wire 1140 may be disposed withinhousing tube 1100 wherein a portion of wire 1140 may be adjacent to aportion of first housing tube portion 1120. In one or more embodiments,a portion of wire 1140 may be fixed to an inner portion of housing tube1100, e.g., by a biocompatible adhesive or any other suitable fixationmeans.

FIG. 12 is a schematic diagram illustrating an exploded view of asteerable laser probe assembly 1200. In one or more embodiments, asteerable laser probe assembly 1200 may comprise a handle assembly 900,a housing tube 1100 having a housing tube distal end 1101 and a housingtube proximal end 1102, a wire 1140 having a wire distal end 1141 and awire proximal loop 1142, an optic fiber 1150 having an optic fiberdistal end 1151 and an optic fiber proximal end 1152, a fixationmechanism 1210, and a light source interface 1220. Illustratively, lightsource interface 1220 may be configured to interface with optic fiberproximal end 1152. In one or more embodiments, light source interface1220 may comprise a standard light source connecter, e.g., an SMAconnector.

Illustratively, housing tube 1100 may be disposed within housing tubehousing 980 and housing tube guide 985. In one or more embodiments,housing tube 1100 may be fixed within housing tube housing 980, e.g.,housing tube proximal end 1102 may be fixed within housing tube housing980. Illustratively, housing tube 1100 may be fixed within housing tubehousing 980, e.g., by an adhesive or by any suitable fixation means. Inone or more embodiments, an actuation of actuation mechanism 920 may beconfigured to actuate housing tube 1100. Illustratively, actuationcontrol 930 may be configured to control an actuation of housing tube1100. In one or more embodiments, an actuation of actuation control 930within actuation channel 935 may be configured to actuate housing tube1100 relative to handle base 940. Illustratively, an actuation ofactuation control distal end 931 towards actuation channel distal end936 may be configured to extend housing tube 1100 relative to handleproximal end 1002. In one or more embodiments, an actuation of actuationcontrol proximal end 932 towards actuation channel proximal end 937 maybe configured to retract housing tube 1100 relative to handle proximalend 1002.

Illustratively, optic fiber 1150 may be disposed within inner bore 960,actuation mechanism guide 970, housing tube housing 980, housing tubeguide 985, and housing tube 1100. In one or more embodiments, opticfiber 1150 may be disposed within housing tube 1100 wherein optic fiberdistal end 1151 may be adjacent to housing tube distal end 1101.Illustratively, a portion of optic fiber 1150 may be fixed to an innerportion of housing tube 1100, e.g., by an adhesive or any suitablefixation means.

In one or more embodiments, wire 1140 may be disposed within fixationmechanism housing 950, inner bore 960, actuation mechanism guide 970,housing tube housing, housing tube guide 985, and housing tube 1100.Illustratively, a portion of wire 1140 may be fixed to an inner portionof housing tube 1100, e.g., by an adhesive or any suitable fixationmeans. In one or more embodiments, fixation mechanism 1210 may bedisposed within fixation mechanism housing 950. Illustratively, fixationmechanism 1210 may be configured to fix wire 1140 in a position relativeto handle 1000, e.g., at fixation mechanism housing 950. In one or moreembodiments, fixation mechanism 1210 may comprise a set screw configuredto fix wire 1140 in a position relative to handle 1000, e.g., by fixingwire proximal loop 1142 in a position within handle 1000. For example,wire proximal loop 1142 may be looped around fixation mechanism 1210,e.g., fixation mechanism 1210 may be disposed within wire proximal loop1142. Illustratively, wire 1140 may be fixed to fixation mechanism 1210,e.g., by an adhesive or any suitable fixation means. For example,fixation mechanism 1210 may be configured to fix wire 1140 in a positionrelative to handle 1000, e.g., by an interference fit. Illustratively,wire 1140 may be fixed in a position relative to handle 1000, e.g., byfixation mechanism 1210, and wire 1140 may also be fixed to an innerportion of housing tube 1100, e.g., a first housing tube portion 1120.

In one or more embodiments, an actuation of actuation mechanism 920 maybe configured to actuate housing tube 1100 relative to wire 1140.Illustratively, actuation control 930 may be configured to control anactuation of actuation mechanism 920 and housing tube 1100. In one ormore embodiments, an actuation of actuation control distal end 931towards actuation channel distal end 936 may be configured to actuateactuation mechanism distal end 921 towards handle distal end 1001.Illustratively, an actuation of actuation mechanism distal end 921towards handle distal end 1001 may be configured to extend housing tube1100 relative to wire 1140 and handle proximal end 1002. In one or moreembodiments, an actuation of actuation control proximal end 932 towardsactuation channel proximal end 937 may be configured to actuateactuation mechanism proximal end 922 towards handle proximal end 1002.Illustratively, an actuation of actuation mechanism proximal end 922towards handle proximal end 1002 may be configured to retract housingtube 1100 relative to wire 1140 and handle proximal end 1002.

In one or more embodiments, wire 1140 may be configured to resist anextension of housing tube 1100 relative to handle proximal end 1002.Illustratively, wire 1140 may be fixed in a position relative to handle1000, e.g., by fixation mechanism 1210, and a portion of wire 1140 maybe fixed to an inner portion of housing tube 1100, e.g., a first housingtube portion 1120. In one or more embodiments, as housing tube 1100 isextended relative to handle proximal end 1002, e.g., due to an actuationof actuation mechanism distal end 921 towards handle distal end 1001,wire 1140 may be configured to resist the extension of housing tube 1100relative to handle proximal end 1002. Illustratively, as housing tube1100 is gradually extended relative to handle proximal end 1002, wire1140 may be configured to gradually compress a portion of housing tube1100, e.g., a first housing tube portion 1120, causing housing tube 1100to gradually curve. In one or more embodiments, a gradual curving ofhousing tube 1100 may be configured to gradually curve optic fiber 1150.

Illustratively, a retraction of housing tube 1100 relative to handleproximal end 1002, e.g., due to an actuation of actuation mechanismproximal end 922 towards handle proximal end 1002, may be configured toreduce a compressive force applied, e.g., by wire 1140, to a portion ofhousing tube 1100. In one or more embodiments, a gradual refraction ofhousing tube 1100 relative to handle proximal end 1002 may be configuredto gradually decompress a portion of housing tube 1100, e.g., a firsthousing tube portion 1120, causing housing tube 1100 to graduallystraighten. Illustratively, a gradual straightening of housing tube 1100may be configured to gradually straighten optic fiber 1150.

In one or more embodiments, an extension of actuation control 930relative to handle proximal end 1002 may comprise an actuation ofactuation control distal end 931 towards actuation channel distal end936. Illustratively, actuation control 930 may be fully extendedrelative to handle proximal end 1002, e.g., when actuation controldistal end 931 is adjacent to actuation channel distal end 936. In oneor more embodiments, an extension of actuation mechanism 920 relative tohandle proximal end 1002 may comprise an actuation of actuationmechanism distal end 921 towards handle distal end 1001. Illustratively,an extension of actuation control 930 relative to handle proximal end1002 may be configured to cause an extension of actuation mechanism 920relative to handle proximal end 1002. In one or more embodiments, anextension of actuation mechanism 920 relative to handle proximal end1002 may be configured to extend housing tube 1100 relative to handleproximal end 1002 and wire 1140. Illustratively, an extension of housingtube 1100 relative to wire 1140 may be configured to curve housing tube1100. In one or more embodiments, a curving of housing tube 1100 may beconfigured to curve optic fiber 1150.

In one or more embodiments, a retraction of actuation control 930relative to handle proximal end 1002 may comprise an actuation ofactuation control proximal end 932 towards actuation channel proximalend 937. Illustratively, actuation control 930 may be fully retractedrelative to handle proximal end 1002, e.g., when actuation controlproximal end 932 is adjacent to actuation channel proximal end 937. Inone or more embodiments, a refraction of actuation mechanism 920relative to handle proximal end 1002 may comprise an actuation ofactuation mechanism proximal end 922 towards handle proximal end 1002.Illustratively, a retraction of actuation control 930 relative to handleproximal end 1002 may be configured to cause a retraction of actuationmechanism 920 relative to handle proximal end 1002. In one or moreembodiments, a retraction of actuation mechanism 920 relative to handleproximal end 1002 may be configured to retract housing tube 1100relative to handle proximal end 1002 and wire 1140. Illustratively, aretraction of housing tube 1100 relative to wire 1140 may be configuredto straighten housing tube 1100. In one or more embodiments, astraightening of housing tube 1100 may be configured to straighten opticfiber 1150.

FIGS. 13A, 13B, 13C, 13D, and 13E illustrate a gradual curving of anoptic fiber 1150. FIG. 13A illustrates a straight optic fiber 1300. Inone or more embodiments, optic fiber 1150 may comprise a straight opticfiber 1300, e.g., when actuation control 930 is fully retracted relativeto handle proximal end 1002. Illustratively, optic fiber 1150 maycomprise a straight optic fiber 1300, e.g., when first housing tubeportion 1120 is fully decompressed. In one or more embodiments, a linetangent to optic fiber distal end 1151 may be parallel to a line tangentto housing tube proximal end 1102, e.g., when optic fiber 1150 comprisesa straight optic fiber 1300.

FIG. 13B illustrates an optic fiber in a first curved position 1310.Illustratively, an extension of actuation control 930 relative to handleproximal end 1002 may be configured to extend housing tube 1100 relativeto wire 1140. In one or more embodiments, an extension of housing tube1100 relative to wire 1140 may be configured to cause wire 1140 tocompress a portion of housing tube 1100 causing housing tube 1100 togradually curve. Illustratively, a gradual curving of housing tube 1100may be configured to gradually curve optic fiber 1150. In one or moreembodiments, an extension of actuation control 930 relative to handleproximal end 1002 may be configured to gradually curve optic fiber 1150from a straight optic fiber 1300 to an optic fiber in a first curvedposition 1310. Illustratively, an extension of actuation mechanism 920relative to handle proximal end 1002 may be configured to extend housingtube 1100 relative to wire 1140. In one or more embodiments, anextension of housing tube 1100 relative to wire 1140 may be configuredto gradually curve optic fiber 1150 from a straight optic fiber 1300 toan optic fiber in a first curved position 1310. Illustratively, a linetangent to optic fiber distal end 1151 may intersect a line tangent tohousing tube proximal end 1102 at a first angle, e.g., when optic fiber1150 comprises an optic fiber in a first curved position 1310. In one ormore embodiments, the first angle may comprise any angle greater thanzero degrees. For example, the first angle may comprise a 45 degreeangle.

FIG. 13C illustrates an optic fiber in a second curved position 1320.Illustratively, an extension of actuation control 930 relative to handleproximal end 1002 may be configured to extend housing tube 1100 relativeto wire 1140. In one or more embodiments, an extension of housing tube1100 relative to wire 1140 may be configured to cause wire 1140 tocompress a portion of housing tube 1100 causing housing tube 1100 togradually curve. Illustratively, a gradual curving of housing tube 1100may be configured to gradually curve optic fiber 1150. In one or moreembodiments, an extension of actuation control 930 relative to handleproximal end 1002 may be configured to gradually curve optic fiber 1150from an optic fiber in a first curved position 1310 to an optic fiber ina second curved position 1320. Illustratively, an extension of actuationmechanism 920 relative to handle proximal end 1002 may be configured toextend housing tube 1100 relative to wire 1140. In one or moreembodiments, an extension of housing tube 1100 relative to wire 1140 maybe configured to gradually curve optic fiber 1150 from an optic fiber ina first curved position 1310 to an optic fiber in a second curvedposition 1320. Illustratively, a line tangent to optic fiber distal end1151 may intersect a line tangent to housing tube proximal end 1102 at asecond angle, e.g., when optic fiber 1150 comprises an optic fiber in asecond curved position 1320. In one or more embodiments, the secondangle may comprise any angle greater than the first angle. For example,the second angle may comprise a 90 degree angle.

FIG. 13D illustrates an optic fiber in a third curved position 1330.Illustratively, an extension of actuation control 930 relative to handleproximal end 1002 may be configured to extend housing tube 1100 relativeto wire 1140. In one or more embodiments, an extension of housing tube1100 relative to wire 1140 may be configured to cause wire 1140 tocompress a portion of housing tube 1100 causing housing tube 1100 togradually curve. Illustratively, a gradual curving of housing tube 1100may be configured to gradually curve optic fiber 1150. In one or moreembodiments, an extension of actuation control 930 relative to handleproximal end 1002 may be configured to gradually curve optic fiber 1150from an optic fiber in a second curved position 1320 to an optic fiberin a third curved position 1330. Illustratively, an extension ofactuation mechanism 920 relative to handle proximal end 1002 may beconfigured to extend housing tube 1100 relative to wire 1140. In one ormore embodiments, an extension of housing tube 1100 relative to wire1140 may be configured to gradually curve optic fiber 1150 from an opticfiber an optic fiber in a second curved position 1320 to an optic fiberin a third curved position 1330. Illustratively, a line tangent to opticfiber distal end 1151 may intersect a line tangent to housing tubeproximal end 1102 at a third angle, e.g., when optic fiber 1150comprises an optic fiber in a third curved position 1330. In one or moreembodiments, the third angle may comprise any angle greater than thesecond angle. For example, the third angle may comprise a 135 degreeangle.

FIG. 13E illustrates an optic fiber in a fourth curved position 1340.Illustratively, an extension of actuation control 930 relative to handleproximal end 1002 may be configured to extend housing tube 1100 relativeto wire 1140. In one or more embodiments, an extension of housing tube1100 relative to wire 1140 may be configured to cause wire 1140 tocompress a portion of housing tube 1100 causing housing tube 1100 togradually curve. Illustratively, a gradual curving of housing tube 1100may be configured to gradually curve optic fiber 1150. In one or moreembodiments, an extension of actuation control 930 relative to handleproximal end 1002 may be configured to gradually curve optic fiber 1150from an optic fiber in a third curved position 1330 to an optic fiber ina fourth curved position 1340. Illustratively, an extension of actuationmechanism 920 relative to handle proximal end 1002 may be configured toextend housing tube 1100 relative to wire 1140. In one or moreembodiments, an extension of housing tube 1100 relative to wire 1140 maybe configured to gradually curve optic fiber 1150 from an optic fiber anan optic fiber in a third curved position 1330 to an optic fiber in afourth curved position 1340. For example, a line tangent to optic fiberdistal end 1151 may be parallel to a line tangent to housing tubeproximal end 1102, e.g., when optic fiber 1150 comprises an optic fiberin a fourth curved position 1340.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a stiffness of first housing tube portion1120 or a stiffness of second housing tube portion 1130 may be adjustedto vary an amount of actuation of actuation mechanism 920 configured tocurve housing tube 1100 to a particular curved position. Illustratively,a material comprising first housing tube portion 1120 or a materialcomprising second housing tube portion 1130 may be adjusted to vary anamount of actuation of actuation mechanism 920 configured to curvehousing tube 1100 to a particular curved position. In one or moreembodiments, an inner diameter of first housing tube portion 1120 or aninner diameter of second housing tube portion 1130 may be adjusted tovary an amount of actuation structure 920 configured to curve housingtube 1100 to a particular curved position. Illustratively, an outerdiameter of first housing tube portion 1120 or an outer diameter ofsecond housing tube portion 1130 may be adjusted to vary an amount ofactuation structure 920 configured to curve housing tube 1100 to aparticular curved position.

In one or more embodiments, a number of apertures in housing tube 1100may be adjusted to vary an amount of actuation of actuation mechanism920 configured to curve housing tube 1100 to a particular curvedposition. Illustratively, a location of one or more apertures in housingtube 1100 may be adjusted to vary an amount of actuation of actuationmechanism 920 configured to curve housing tube 1100 to a particularcurved position. In one or more embodiments, a geometry of one or moreapertures in housing tube 1100 may be adjusted to vary an amount ofactuation of actuation mechanism 920 configured to curve housing tube1100 to a particular curved position. Illustratively, a geometry of oneor more apertures in housing tube 1100 may be uniform, e.g., eachaperture of the one or more apertures may have a same geometry. In oneor more embodiments, a geometry of one or more apertures in housing tube1100 may be non-uniform, e.g., a first aperture in housing tube 1100 mayhave a first geometry and a second aperture in housing tube 1100 mayhave a second geometry.

Illustratively, a geometry or shape of actuation mechanism 920 may beadjusted to vary an amount actuation of actuation mechanism 920configured to curve housing tube 1100 to a particular curved position.In one or more embodiments, one or more locations within housing tube1100 wherein wire 1140 may be fixed to an inner portion of housing tube1100 may be adjusted to vary an amount of actuation of actuationmechanism 920 configured to curve housing tube 1100 to a particularcurved position. Illustratively, at least a portion of optic fiber 1150may be enclosed in an optic fiber sleeve configured to, e.g., protectoptic fiber 1150, vary a stiffness of optic fiber 1150, vary an opticalproperty of optic fiber 1150, etc. In one or more embodiments, a portionof optic fiber 1150 that may be fixed to an inner portion of housingtube 1100 may be enclosed in an optic fiber sleeve configured to, e.g.,protect optic fiber 1150, facilitate a fixation, etc. Illustratively, aportion of housing tube 1100 may comprise an access window, e.g.,configured to allow access to an inner portion of housing tube 1100. Inone or more embodiments, a portion of housing tube 1100 may comprise anaccess window, e.g., configured to allow access to a portion of wire1140 or a portion of optic fiber 1150.

Illustratively, a stiffness of first housing tube portion 1120 or astiffness of second housing tube portion 1130 may be adjusted to vary abend radius of housing tube 1100. In one or more embodiments, astiffness of first housing tube portion 1120 or a stiffness of secondhousing tube portion 1130 may be adjusted to vary a radius of curvatureof housing tube 1100, e.g., when housing tube 1100 is in a particularcurved position. Illustratively, a number of apertures in housing tube1100 may be adjusted to vary a bend radius of housing tube 1100. In oneor more embodiments, a number of apertures in housing tube 1100 may beadjusted to vary a radius of curvature of housing tube 1100, e.g., whenhousing tube 1100 is in a particular curved position. Illustratively, alocation or a geometry of one or more apertures in housing tube 1100 maybe adjusted to vary a bend radius of housing tube 1100. In one or moreembodiments, a location or a geometry of one or more apertures inhousing tube 1100 may be adjusted to vary a radius of curvature ofhousing tube 1100, e.g., when housing tube 1100 is in a particularcurved position.

FIGS. 14A, 14B, 14C, 14D, and 14E illustrate a gradual straightening ofan optic fiber 1150. FIG. 14A illustrates a fully curved optic fiber1400. In one or more embodiments, optic fiber 1150 may comprise a fullycurved optic fiber 1400, e.g., when actuation control 930 is fullyextended relative to handle proximal end 1002. Illustratively, opticfiber 1150 may comprise a fully curved optic fiber 1400, e.g., whenfirst housing tube portion 1120 is fully compressed. In one or moreembodiments, a line tangent to optic fiber distal end 1151 may beparallel to a line tangent to housing tube proximal end 1102, e.g., whenoptic fiber 1150 comprises a straight optic fiber 1400.

FIG. 14B illustrates an optic fiber in a first partially straightenedposition 1410. Illustratively, a refraction of actuation control 930relative to handle proximal end 1002 may be configured to retracthousing tube 1100 relative to wire 1140. In one or more embodiments, arefraction of housing tube 1100 relative to wire 1140 may be configuredto cause wire 1140 to decompress a portion of housing tube 1100, e.g., afirst housing tube portion 1120, causing housing tube 1100 to graduallystraighten. Illustratively, a gradual straightening of housing tube 1100may be configured to gradually straighten optic fiber 1150. In one ormore embodiments, a retraction of actuation control 930 relative tohandle proximal end 1002 may be configured to gradually straighten opticfiber 1150 from a fully curved optic fiber 1400 to an optic fiber in afirst partially straightened position 1410. Illustratively, a retractionof actuation mechanism 920 relative to handle proximal end 1002 may beconfigured to retract housing tube 1100 relative to wire 1140. In one ormore embodiments, a retraction of housing tube 1100 relative to wire1140 may be configured to gradually straighten optic fiber 1150 from afully curved optic fiber 1400 to an optic fiber in a first partiallystraightened position 1410. Illustratively, a line tangent to opticfiber distal end 1151 may intersect a line tangent to housing tubeproximal end 1102 at a first partially straightened angle, e.g., whenoptic fiber 1150 comprises an optic fiber in a first partiallystraightened position 1410. Illustratively, the first partiallystraightened angle may comprise any angle less than 180 degrees. Forexample, the first partially straightened angle may comprise a 135degree angle.

FIG. 14C illustrates an optic fiber in a second partially straightenedposition 1420. Illustratively, a retraction of actuation control 930relative to handle proximal end 1002 may be configured to retracthousing tube 1100 relative to wire 1140. In one or more embodiments, aretraction of housing tube 1100 relative to wire 1140 may be configuredto cause wire 1140 to decompress a portion of housing tube 1100, e.g., afirst housing tube portion 1120, causing housing tube 1100 to graduallystraighten. Illustratively, a gradual straightening of housing tube 1100may be configured to gradually straighten optic fiber 1150. In one ormore embodiments, a retraction of actuation control 930 relative tohandle proximal end 1002 may be configured to gradually straighten opticfiber 1150 from an optic fiber in a first partially straightenedposition 1410 to an optic fiber in a second partially straightenedposition 1420. Illustratively, a retraction of actuation mechanism 920relative to handle proximal end 1002 may be configured to retracthousing tube 1100 relative to wire 1140. In one or more embodiments, aretraction of housing tube 1100 relative to wire 1140 may be configuredto gradually straighten optic fiber 1150 from an optic fiber in a firstpartially straightened position 1410 to an optic fiber in a secondpartially straightened position 1420. Illustratively, a line tangent tooptic fiber distal end 1151 may intersect a line tangent to housing tubeproximal end 1102 at a second partially straightened angle, e.g., whenoptic fiber 1150 comprises an optic fiber in a second partiallystraightened position 1420. Illustratively, the second partiallystraightened angle may comprise any angle less than the first partiallystraightened angle. For example, the second partially straightened anglemay comprise a 90 degree angle.

FIG. 14D illustrates an optic fiber in a third partially straightenedposition 1430. Illustratively, a retraction of actuation control 930relative to handle proximal end 1002 may be configured to retracthousing tube 1100 relative to wire 1140. In one or more embodiments, arefraction of housing tube 1100 relative to wire 1140 may be configuredto cause wire 1140 to decompress a portion of housing tube 1100, e.g., afirst housing tube portion 1120, causing housing tube 1100 to graduallystraighten. Illustratively, a gradual straightening of housing tube 1100may be configured to gradually straighten optic fiber 1150. In one ormore embodiments, a retraction of actuation control 930 relative tohandle proximal end 1002 may be configured to gradually straighten opticfiber 1150 from an optic fiber in a second partially straightenedposition 1420 to an optic fiber in a third partially straightenedposition 1430. Illustratively, a retraction of actuation mechanism 920relative to handle proximal end 1002 may be configured to retracthousing tube 1100 relative to wire 1140. In one or more embodiments, arefraction of housing tube 1100 relative to wire 1140 may be configuredto gradually straighten optic fiber 1150 from an optic fiber in a secondpartially straightened position 1420 to an optic fiber in a thirdpartially straightened position 1430. Illustratively, a line tangent tooptic fiber distal end 1151 may intersect a line tangent to housing tubeproximal end 1102 at a third partially straightened angle, e.g., whenoptic fiber 1150 comprises an optic fiber in a third partiallystraightened position 1430. Illustratively, the third partiallystraightened angle may comprise any angle less than the second partiallystraightened angle. For example, the third partially straightened anglemay comprise a 45 degree angle.

FIG. 14E illustrates an optic fiber in a fully straightened position1440. Illustratively, a retraction of actuation control 930 relative tohandle proximal end 1002 may be configured to retract housing tube 1100relative to wire 1140. In one or more embodiments, a refraction ofhousing tube 1100 relative to wire 1140 may be configured to cause wire1140 to decompress a portion of housing tube 1100, e.g., a first housingtube portion 1120, causing housing tube 1100 to gradually straighten.Illustratively, a gradual straightening of housing tube 1100 may beconfigured to gradually straighten optic fiber 1150. In one or moreembodiments, a retraction of actuation control 930 relative to handleproximal end 1002 may be configured to gradually straighten optic fiber1150 from an optic fiber in a third partially straightened position 1430to an optic fiber in a fully straightened position 1440. Illustratively,a retraction of actuation mechanism 920 relative to handle proximal end1002 may be configured to retract housing tube 1100 relative to wire1140. In one or more embodiments, a retraction of housing tube 1100relative to wire 1140 may be configured to gradually straighten opticfiber 1150 from an optic fiber in a third partially straightenedposition 1430 to an optic fiber in a fully straightened position 1440.Illustratively, a line tangent to optic fiber distal end 1151 may beparallel to a line tangent to housing tube proximal end 1102, e.g., whenoptic fiber 1150 comprises an optic fiber in a fully straightenedposition 1440.

Illustratively, a surgeon may aim optic fiber distal end 1151 at any ofa plurality of targets within an eye, e.g., to perform aphotocoagulation procedure. In one or more embodiments, a surgeon mayaim optic fiber distal end 1151 at any target within a particulartransverse plane of the inner eye by, e.g., rotating handle 1000 toorient housing tube 1100 in an orientation configured to cause acurvature of housing tube 1100 within the particular transverse plane ofthe inner eye and varying an amount of actuation of actuation mechanism920. Illustratively, a surgeon may aim optic fiber distal end 1151 atany target within a particular sagittal plane of the inner eye by, e.g.,rotating handle 1000 to orient housing tube 1100 in an orientationconfigured to cause a curvature of housing tube 1100 within theparticular sagittal plane of the inner eye and varying an amount ofactuation of actuation mechanism 920. In one or more embodiments, asurgeon may aim optic fiber distal end 1151 at any target within aparticular frontal plane of the inner eye by, e.g., varying an amount ofactuation of actuation mechanism 920 to orient a line tangent to opticfiber distal end 1151 wherein the line tangent to optic fiber distal end1151 is within the particular frontal plane of the inner eye androtating handle 1000. Illustratively, a surgeon may aim optic fiberdistal end 1151 at any target located outside of the particulartransverse plane, the particular sagittal plane, and the particularfrontal plane of the inner eye, e.g., by varying a rotationalorientation of handle 1000 and varying an amount of actuation ofactuation mechanism 920. In one or more embodiments, a surgeon may aimoptic fiber distal end 1151 at any target of a plurality of targetswithin an eye, e.g., without increasing a length of a portion of asteerable laser probe within the eye. Illustratively, a surgeon may aimoptic fiber distal end 1151 at any target of a plurality of targetswithin an eye, e.g., without decreasing a length of a portion of asteerable laser probe within the eye.

FIGS. 15A and 15B are schematic diagrams illustrating an exploded viewof a handle assembly 1500. FIG. 15A illustrates a side view of a handleassembly 1500. In one or more embodiments, a handle assembly 1500 maycomprise an outer cylinder 910, an actuation mechanism 920, and a handlebase 940. Illustratively, actuation mechanism 920 may comprise anactuation control 930. In one or more embodiments, handle base 940 maycomprise an actuation channel 935. Illustratively, actuation mechanism920 may comprise an actuating chamber 1510. FIG. 15B illustrates atransparent top view of a handle assembly 1500. In one or moreembodiments, handle base 940 may comprise one or more static chambers1520.

FIGS. 16A and 16B are schematic diagrams illustrating a handle 1600.FIG. 16A illustrates a transparent top view of handle 1600. In one ormore embodiments, actuation control 930 may be disposed within actuationchannel 935. FIG. 16B illustrates a trans-parent side view of handle1600. Illustratively, an actuating chamber 1510 may be configured toalign with one or more static chambers 1520. In one or more embodiments,one or more static chambers 1520 may be configured to temporarily fixactuation control 930 in a position within actuation channel 935. Forexample, a first static chamber 1520 may be configured to temporarilyfix actuation control 930 in a first position within actuation channel935, a second static chamber 1520 may be configured to temporarily fixactuation control 930 in a second position within actuation channel 935,a third static chamber 1520 may be configured to temporarily fixactuation control 930 in a third position within actuation channel 935,a forth static chamber 1520 may be configured to temporarily fixactuation control 930 in a forth position within actuation channel 935,etc.

Illustratively, a static chamber 1520 may be configured to interfacewith actuating chamber 1510, e.g., to temporarily fix actuation control930 in a position within actuation channel 935. In one or moreembodiments, an interface between a static chamber 1520 and actuationchamber 1510 may be configured to align a static chamber 1520 andactuation chamber 1510 wherein a fixation pin may be temporarilydisposed within a static chamber 1520 and within actuation chamber 1510.Illustratively, a fixation pin may be temporarily disposed within astatic chamber 1520 and within actuation chamber 1510, e.g., by pushingthe fixation pin into a static chamber 1520 and into actuation chamber1510. In one or more embodiments, actuation control 930 may betemporarily fixed in a position within actuation channel 935, e.g., whena fixation pin is disposed within a static chamber 1520 and withinactuation chamber 1510. Illustratively, removing a fixation pin fromactuation chamber 1510 may be configured to allow actuation control 930actuate within actuation channel 935. In one or more embodiments, afixation pin may be removed from actuation chamber 1510, e.g., bypulling the fixation pin out of actuation chamber 1510.

Illustratively, one or more static chambers 1520 may be configured tohouse one or more magnets. In one or more embodiments, actuation chamber1510 may be configured to house one or more magnets. Illustratively, oneor more magnets may be configured to temporarily fix actuation control930 in a position within actuation channel 935. In one or moreembodiments, one or more magnets may be disposed within a static chamber1520 wherein one or more magnetic poles of the one or more magnets maybe oriented to cause an attractive force between one or more magnets andactuation control 930, e.g., when actuation chamber 1510 is adjacent toa static chamber 1520. Illustratively, one or more magnets may bedisposed within actuation chamber 1510 wherein one or more magneticpoles of the one or more magnets may be oriented to cause an attractiveforce between one or more magnets and a static chamber 1520, e.g., whenactuation chamber 1510 is adjacent to a static chamber 1520. In one ormore embodiments, one or more magnets may be configured to cause one ormore attractive forces configured to temporarily fix actuation control930 in a position within actuation channel 935. For example, anattractive force configured to temporarily fix actuation control 930 ina position within actuation channel 935 may have a magnitude in therange of 1 to 50 N. However, an attractive force configured totemporarily fix actuation control 930 in a position within actuationchannel 935 may have a magnitude less than 1 N or a magnitude greaterthan 50 N. Illustratively, an application of a force, e.g., a forcehaving a magnitude greater than a magnitude of an attractive force, toactuation control 930 may be configured to actuate actuation control 930within actuation channel 935.

In one or more embodiments, temporarily fixing actuation control 930 ina position within actuation channel 935 may be configured to temporarilyfix housing tube 1100 in a particular curved position. Illustratively,temporarily fixing housing tube 1100 in a particular curved position maybe configured to temporarily fix optic fiber 1150 in a particular curvedposition. In one or more embodiments, a first static chamber 1520 may beconfigured to temporarily fix housing tube 1100 in a particular curvedposition wherein optic fiber 1150 may comprise an optic fiber in a firstcurved position 1310, a second static chamber 1520 may be configured totemporarily fix housing tube 1100 in a particular curved positionwherein optic fiber 1150 may comprise an optic fiber in a second curvedposition 1320, a third static chamber 1520 may be configured totemporarily fix housing tube 1100 in a particular curved positionwherein optic fiber 1150 may comprise an optic fiber in a third curvedposition 1330, a fourth static chamber 1520 may be configured totemporarily fix housing tube 1100 in a particular curved positionwherein optic fiber 1150 may comprise an optic fiber in a fourth curvedposition 1340, etc.

The foregoing description has been directed to particular embodiments ofthis invention. It will be apparent; however, that other variations andmodifications may be made to the described embodiments, with theattainment of some or all of their advantages. Specifically, it shouldbe noted that the principles of the present invention may be implementedin any probe system. Furthermore, while this description has beenwritten in terms of a steerable laser probe, the teachings of thepresent invention are equally suitable to systems where thefunctionality of actuation may be employed. Therefore, it is the objectof the appended claims to cover all such variations and modifications ascome within the true spirit and scope of the invention.

What is claimed is:
 1. An instrument comprising: a handle having ahandle distal end and a handle proximal end; an actuation control of thehandle; a housing tube having a housing tube distal end and a housingtube proximal end; a first housing tube portion of the housing tube, thefirst housing tube portion having a first stiffness; a second housingtube portion of the housing tube, the second housing tube portion havinga second stiffness wherein the second stiffness is greater than thefirst stiffness; and an optic fiber disposed in an inner bore of thehandle and the housing tube, the optic fiber configured to transmitlight.
 2. The instrument of claim 1 wherein an extension of theactuation control relative to the handle proximal end is configured togradually curve the optic fiber.
 3. The instrument of claim 2 whereinthe extension of the actuation control relative to the handle proximalend is configured to gradually curve the housing tube.
 4. The instrumentof claim 3 wherein the extension of the actuation control relative tothe handle proximal end is configured to gradually extend the housingtube relative to the optic fiber.
 5. The instrument of claim 4 whereinthe extension of the actuation control relative to the handle proximalend is configured to gradually compress a portion of the housing tube.6. The instrument of claim 1 further comprising: an actuation chamber ofthe handle; and a first static chamber of the handle, the actuationchamber and the first static chamber configured to temporarily fix theactuation control in a first position within an actuation channel of thehandle.
 7. The instrument of claim 6 wherein temporarily fixing theactuation control in the first position within the actuation channel ofthe handle is configured to temporarily fix the optic fiber in a firstcurved position.
 8. The instrument of claim 6 further comprising: asecond static chamber of the handle, the actuation chamber and thesecond static chamber of the handle configured to temporarily fix theactuation control in a second position within the actuation channel ofthe handle.
 9. The instrument of claim 8 wherein temporarily fixing theactuation control in the second position within the actuation channel ofthe handle is configured to temporarily fix the optic fiber in a secondcurved position.
 10. The instrument of claim 8 further comprising: athird static chamber of the handle, the actuation chamber and the thirdstatic chamber of the handle configured to temporarily fix the actuationcontrol in a third position within the actuation channel of the handle.11. The instrument of claim 10 wherein temporarily fixing the actuationcontrol in the third position within the actuation channel of the handleis configured to temporarily fix the optic fiber in a third curvedposition.
 12. The instrument of claim 10 further comprising: a fourthstatic chamber of the handle, the actuation chamber and the fourthstatic chamber of the handle configured to temporarily fix the actuationcontrol in a fourth position within the actuation channel of the handle.13. The instrument of claim 12 wherein temporarily fixing the actuationcontrol within the fourth position within the actuation channel of thehandle is configured to temporarily fix the optic fiber in a fourthcurved position.
 14. The instrument of claim 1 further comprising: awire disposed in the housing tube and the inner bore of the handle; anda portion of the wire fixed to the housing tube.
 15. The instrument ofclaim 14 wherein an extension of the actuation control relative to thehandle proximal end is configured to gradually curve the optic fiber.16. The instrument of claim 14 wherein a retraction of the actuationcontrol relative to the handle proximal end is configured to graduallystraighten the optic fiber.
 17. A method comprising: actuating anactuation control of a handle; extending a housing tube relative to awire; compressing a portion of the housing tube; curving the housingtube to a first curved position; aiming a distal end of an optic fiberat a first photocoagulation target within an eye; and fixing the housingtube in the first curved position.
 18. A method comprising: applying aforce to an actuation control of a handle; actuating the actuationcontrol; curving an optic fiber to a first curved position; fixing theoptic fiber in the first curved position; removing the force applied tothe actuation control; performing a first portion of a laserphotocoagulation surgical procedure; and curving the optic fiber to asecond curved position.
 19. The method of claim 18 further comprising:fixing the optic fiber in the second curved position; and performing asecond portion of the laser photocoagulation surgical procedure.
 20. Themethod of claim 19 further comprising: curving the optic fiber to athird curved position.